ABSTRACT
Hypertensive renal damage is one of the most serious complications of hypertension, and it is also the main cause of end-stage renal disease. Renal damage can further promote the rise of blood pressure and difficult to control, forming a vicious circle. Traditional Chinese medicine (TCM) considers that deficiency of the original and excess of the standard is its basic pathogenesis, and insufficient kidney-Qi and blood stasis are one of the most common syndromes of hypertensive kidney damage. Astragali Radix membranaceus is praised as the most important medicine for invigorating Qi, and Salviae Miltiorrhizae Radix is likened to "four things with the same function". Based on the theory of invigorating Qi and activating blood circulation, the effective ingredients of Astragali Radix membranaceus-Salviae Miltiorrhizae Radix are mainly astragaloside, Astragali Radix polysaccharide, mulberry isoflavone, salvianolic acid and tanshinone. Many studies have shown that in the process of hypertensive kidney damage, Astragali Radix membranaceu Its active ingredients, whether effective monomers, monomer compatibility or direct compatibility of drug pairs, can regulate blood pressure, reduce urinary protein, protect renal tubules, protect glomerular filtration barrier, improve renal hemodynamics and protect renal function by regulating multiple signal transduction pathways related to hypertensive renal damage. Lowering blood pressure and protecting renal function are two pronged functions. Based on the theory of Invigorating Qi and activating blood circulation, this paper reviews the research progress of Astragali Radix-Salviae Miltiorrhizae Radix in the treatment of hypertensive renal damage, with a view to providing scientific basis for the further study and clinical application of Radix astragali-Salviae Miltiorrhizae Radix in hypertensive renal damage.
ABSTRACT
Objective To evaluate the therapeutic effect and safety of Qingre Jiangya Granule(granule for clearing heat and lowering blood pressure)for the treatment of young adult hypertension patients with flaming-up of the liver fire syndrome.Methods The selected 130 patients were randomized into the treatment group which was administered Qingre Jiangya Granule and the control group which was given Niuhuang Jiangya Pills(bezoar pill for relieving hypertension).Both groups were treated for 4 weeks.Changes in blood pressure,symptoms,blood fat and glucose,hemorheology,and adverse reaction were observed.Results The anti-hypertension effect of the treatment group was significantly superior to that of the control group(P
ABSTRACT
AIM: To explore the action of Zisheng Qingyang Tablet for improving left ventricle hypertrophy of essential hyertension's traditional Chinese medicine syndromes and for lowering blood pressure(BP). METHODS: There were 60 patients, whose syndrome differentiation typing(SDT) was the yin-deficiency and yang-hyperactivity, the deficiency of heart-qi with dizziness caused by wind accompanied cardiac hypertrophy(essential hypertension left ventricle hypertrophy). The 60 patients were randomly divided into treating group and comtrol group each group with 30 patients. 4 months was one course of treatment. Pre-and post-therapy, the total scores of each group, the individual syndrome's scores of each group and the levels of BP were marked. RESULTS: After treating, the TCM syndromes of two groups were relieved. The total scores and improvements of TCM syndromes were markedly higher than that of the control group, and the significance especially displays on relieving main symptoms, such as dizziness, headache, chest distention and palpitation(P0.05). CONCLUSION: Zisheng Qingyang Table can obviously improve TCM syndromes, The effects especially exist in relieving the main symptoms as follows: dizziness, headache, chest distention, palpitation. The action of Zisheng Qingyang Tablet and captopril for lowering BP is alike.